16-P012 Gpg3, a novel ciliogenesis mutant modulating Hh signalling
نویسندگان
چکیده
A novel role for notch signalling in left–right determination through ciliary length control Susana Lopes, Raquel Lourenc o, Luis Pacheco, Nuno Moreno, Jill Kreiling, Leonor Saúde 1 Instituto de Medicina Molecular, Lisbon, Portugal 2 Instituto de Histologia e Biologia do Desenvolviment da Faculdade de Medicina de Lisboa, Lisbon, Portugal 3 Instituto Gulbenkian de Ciência, Oeiras, Portugal 4 Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, United States
منابع مشابه
The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation.
The chicken talpid(3) mutant, with polydactyly and defects in other embryonic regions that depend on hedgehog (Hh) signalling (e.g. the neural tube), has a mutation in KIAA0568. Similar phenotypes are seen in mice and in human syndromes with mutations in genes that encode centrosomal or intraflagella transport proteins. Such mutations lead to defects in primary cilia, sites where Hh signalling ...
متن کاملTargeted mutation of the talpid3 gene in zebrafish reveals its conserved requirement for ciliogenesis and Hedgehog signalling across the vertebrates.
Using zinc-finger nuclease-mediated mutagenesis, we have generated mutant alleles of the zebrafish orthologue of the chicken talpid3 (ta3) gene, which encodes a centrosomal protein that is essential for ciliogenesis. Animals homozygous for these mutant alleles complete embryogenesis normally, but manifest a cystic kidney phenotype during the early larval stages and die within a month of hatchin...
متن کامل16-P011 Wdr35 is required for mammalian ciliogenesis and Hh responsiveness
A novel role for notch signalling in left–right determination through ciliary length control Susana Lopes, Raquel Lourenc o, Luis Pacheco, Nuno Moreno, Jill Kreiling, Leonor Saúde 1 Instituto de Medicina Molecular, Lisbon, Portugal 2 Instituto de Histologia e Biologia do Desenvolviment da Faculdade de Medicina de Lisboa, Lisbon, Portugal 3 Instituto Gulbenkian de Ciência, Oeiras, Portugal 4 Dep...
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The yeast strains that are resistant to high concentration of ethanol have biotechnological benefits and aresuitable models for physiology and molecular genetics research fields. A novel ethanol-tolerant mutant strain,mut1, derived from the commercial Saccharomyces cerevisiae showed higher ethanol production, and alsodemonstrated resistance to ethanol but not to other alcohols...
متن کاملWDR11‐mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome
WDR11 has been implicated in congenital hypogonadotropic hypogonadism (CHH) and Kallmann syndrome (KS), human developmental genetic disorders defined by delayed puberty and infertility. However, WDR11's role in development is poorly understood. Here, we report that WDR11 modulates the Hedgehog (Hh) signalling pathway and is essential for ciliogenesis. Disruption of WDR11 expression in mouse and...
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عنوان ژورنال:
- Mechanisms of Development
دوره 126 شماره
صفحات -
تاریخ انتشار 2009